Suppositories Glycerine Vilardell Infants 0.92 G 6 Suppositories (Blister)

Vilardell Lactating Glycerin Suppositories (0.92 G 6 Suppositories (Blister))

ACTION AND MECHANISM

- [LAXANT]. Glycerol is a polyol derivative that behaves as a laxative when administered rectally. Its effects are due to a double mechanism of action:

* Irritant effect on the rectal mucosa, without affecting the distal walls of the intestine. The local contraction of the rectal muscles causes the expulsion of feces in a short time.

* Osmotic effect. Glycerol has a great hygroscopic capacity, causing the passage of water towards the intestinal lumen. The increase in water, together with the lubricating properties of sorbitol, soften the stool and facilitate its elimination.

The effects take between 15-30 minutes and an hour to appear.

PHARMACOKINETICS

- Absorption: Glycerol is barely absorbed when administered rectally, being almost completely eliminated when defecation occurs. However, oral absorption is high. Maximum oral plasma concentrations are reached within 60-90 minutes.

- Distribution: The absorbed glycerol is widely distributed throughout the body, accumulating in muscle fat.

- Metabolism: It is extensively metabolized in the liver (around 80% of the amount absorbed).

- Elimination: Glycerol is eliminated mainly by hepatic metabolism. In urine, 20% of the absorbed content appears unchanged. The elimination half-life is 30-45 minutes.

INDICATIONS

- [CONSTIPATION]. Symptomatic local treatment of temporary and occasional constipation.

POSOLOGY

- Children and adolescents under 18 years of age, rectally:
* Children under 2 years of age: 1 suppository / 24 h.
It is recommended not to use for periods longer than 6-7 days, except medical criteria. If after this time the symptoms continue or worsen, it is advisable to consult a doctor and / or pharmacist.

RULES FOR CORRECT ADMINISTRATION

- Suppositories: It is recommended to previously harden the suppositories by putting them 30 seconds under the cold water tap or 10 seconds in a glass of water. The suppositories will be inserted deep into the anal opening.

Repress the evacuation for as long as possible so that the medicine exerts its action perfectly.

CONTRAINDICATIONS

- Hypersensitivity to any component of the drug.

- Situations that could be aggravated by the laxative effect, such as [BOWEL OBSTRUCTION], [INTESTINAL PERFORATION], [INFLAMMATORY BOWEL DISEASE] chronic, [APPENDICITIS] or [TOXIC MEGACOLON]. Logically, it should not be used in patients with [DIARRHEA].

PRECAUTIONS

- Symptoms of intestinal obstruction. Before initiating treatment with a laxative, a differential diagnosis of intestinal obstruction is advised in patients with symptoms such as [NAUSEA], [VOMITING] or [ABDOMINAL PAIN] of unknown origin, or [ABDOMINAL DISTENSION].

ADVICE TO THE PATIENT

- Before starting treatment for constipation, lifestyle habits should be changed. It is recommended an adequate daily intake of fluids and fiber, respond quickly to the stimulus of defecation and perform physical exercise.

- This medicine should not be used by patients with intestinal obstructions.

- Consult your doctor and / or pharmacist in case of worsening constipation, or if symptoms such as nausea or vomiting, abdominal swelling or fever appear.

SPECIAL WARNINGS

- Perform a differential diagnosis in patients suspected of intestinal obstruction.

INTERACTIONS

Drug interactions have not been described.

PREGNANCY

This medicine is not indicated for pregnant women.

LACTATION

This medicine is not indicated for breastfeeding women.

KIDS

Young children are often not able to describe their symptoms clearly, so a proper diagnosis must be made before using a laxative to avoid complications from existing conditions, such as appendicitis.

ELDERLY

This medicine is not indicated for the elderly.

ADVERSE REACTIONS

Glycerol adverse reactions are generally mild and transient, and local in nature.

- Digestive. Occasionally irritation, stinging or [ANAL PRURIT] may appear.

OVERDOSE

Symptoms: Using this medicine for long periods of time and at high doses can lead to irritable bowel syndrome.

Treatment: Treatment will be symptomatic. The laxative should be discontinued.

Leaflet Suppositories Glycerin Vilardell Lactantes 0.92 G 6 Suppositories (Blister)