Hurricaine 200 Mg/Ml Topical Gel 6 Ml

Hurricaine (200 Mg / G Oral Gel 1 Tube 6 Ml)

Benzocaine

ACTION AND MECHANISM

It works by blocking the sensory receptors of the mucous membranes, locally. It does not penetrate inside, so it is ineffective in inflammatory or dental pain originating in deep areas of the teeth and gums.
Benzocaine has a really low pK of 3.5, which makes it provide adequate superficial anesthesia. The latency or onset of action period is 30-60 seconds, with the duration of the effect being 10-15 minutes.

PHARMACOKINETICS

Benzocaine is absorbed in a very small amount through the mucous membranes. It is hydrolyzed to PABA-containing metabolites by plasma cholinesterases and, to a much lesser extent, by liver cholinesterases. Excretion is mainly through the kidneys, mainly as metabolites.

INDICATIONS

- Symptomatic relief of [DENTALGIA] and pain in the oral mucosa.

RULES FOR CORRECT ADMINISTRATION

- Hurricaíne mouth gel: apply a small amount of medicine to the area to be treated with small touches. Wash your hands after each application.

The anesthesia caused by this medicine at the level of the throat can promote coughing during the meal, giving the impression of choking. This medicine should not be used before eating or drinking.

CONTRAINDICATIONS

- Hypersensitivity to benzocaine, [ALLERGY TO LOCAL ANESTHETICS TYPE ESTER] or to other derivatives of p-aminobenzoic acid (PABA).

- Children under 2 years of age. Nani-Predental should not be used in children younger than 4 months.

PRECAUTIONS

- [METAHEMOGLOBINEMIA]: Described cases of methemoglobinemia in patients (mostly children under 4 years of age) to whom benzocaine gel or liquid was administered to relieve tooth pain. In most cases the product had been used incorrectly or excessively, although there were also some with proper use. Children under four years of age, elderly patients, and patients with certain congenital malformations such as glucose-6-phosphodiesterase deficiency, hemoglobin-M disease, NADH-methemoglobin reductase (diaphorase 1) deficiency, and pyruvate kinase deficiency may also have increased risk of developing methemoglobinemia.

ADVICE TO THE PATIENT

- Do not use for more than 7 consecutive days.
- Do not apply this medicine more than 4 times a day, always using the smallest dose that relieves pain.
- Do not chew food or gum while numbness persists due to the risk of biting the tongue or oral mucosa.
- The buccal application of benzocaine can cause problems in swallowing and therefore risk of aspiration. So it is recommended not to eat in the hour after its application and avoid spraying in the throat.
- Contains benzocaine so watch out for signs or symptoms of methemoglobinemia such as pale, gray or bluish discoloration of the skin, lips and nails, shortness of breath, fatigue, confusion, headache, dizziness and rapid heart rate.

SPECIAL WARNINGS

- Warn patients of the risk of methemoglobinemia. Symptoms can appear within minutes to an hour or two after using benzocaine. Symptoms can occur with the first or subsequent applications of benzocaine.

INTERACTIONS

- Sulfamides: PABA, a product of benzocaine metabolism, can inhibit the action of sulfonamides. Avoid joint administration

ADVERSE REACTIONS

• With prolonged use of benzocaine, [HYPERSENSITIVITY REACTIONS] (<1%) consisting of [CONTACT DERMATITIS] may occur. Other hypersensitivity reactions such as [EXANTEMATIC ERUPTIONS], [URTICARIA], [EDEMA] or [ANAPHYLAXIA] are extremely rare.
  - Prolonged contact of benzocaine with the mucous membranes can cause dehydration of the epithelium and hardening of the mucous membranes. A burning sensation in the mouth has been described.
  - Due to prolonged use, the following have been reported: [DYSGEUSIA], bad taste in the mouth, dehydration of the mucous membranes and swallowing difficulties.
  - Exceptionally, benzocaine has been associated with the production of [METAHEMOGLOBINEMIA], characterized by [CYANOSIS]. Most cases of methemoglobinemia in children occur from overdose, accidental ingestion, and misuse of benzocaine preparations.

Hurricaine 200 Mg / Ml Topic Gel 6 Ml Leaflet