Daflon 500 500 Mg 30 Coated Tablets

Daflon 30 tablets (Diosmina, Hsperidine) provides relief in adults from the symptoms of mild venous insufficiency of the legs such as: pain, feeling of heaviness, tightness, tingling, itching of legs with several or swollen legs.

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Daflon 500 (500 Mg 30 Coated Tablets)

Diosmin 450mg /Flavonoids expressed as Hesperidin 50mg

 

ACTION AND MECHANISM

Venotonic and vasoprotective. It produces venoconstriction, increases the resistance of the vessels and decreases their permeability.

In the animal, it exerts a double action on the venous return system:

- at the level of veins and venules: it increases parietal tone and exerts an antistatic action;

- at the microcirculation level: normalizes capillary permeability and reinforces capillary resistance.

In man, double-blind controlled studies have confirmed venotonic activity: venous tone increases: mercury ring venous occlusion plethysmography has revealed decreased venous emptying times.

It has also shown activity on microcirculation: in patients who show signs of capillary fragility, capillary resistance measured by angiosterometry increases.

 

PHARMACOKINETICS

Diosmin pharmacokinetics are linear.

Orally:

- Absorption: diosmin is rapidly transformed by the intestinal flora and is absorbed in its aglycone form (diosmetin). Bioavailability: 57.9% approx.

- Distribution: extensive (Vd: 62.1 L).

- Metabolism: Diosmetine is rapidly and widely degraded to phlebotonic acids or its derivatives conjugated with glycine, which are eliminated in the urine. Predominant metabolite: hydroxyphenylpropionic acid (which is mostly eliminated conjugate). Metabolites in smaller quantities: other phenolic acids corresponding to 1-hydroxy-4-methoxybenzoic acid, 3-methoxy-4-hydroxyphenylacetic acid and 3,4-dihydroxybenzoic acid.

- Elimination: relatively fast. In studies with radiolabelled diosmin, 34% of the dose was recovered in urine and faeces after the first 24 hours, and approximately 86% were recovered in urine and faeces after the first 48 hours.

 

INDICATIONS

- Short-term relief (2 to 3 months) of edema and symptoms related to chronic [VENOUS INSUFFICIENCY].

 

POSOLOGY

- Adults: Usual therapeutic dose: 500 mg / 12 h at noon and at night, with meals.

- Children and adolescents <18 years: not recommended.

- Elderly: no dosage adjustment is required.

Treatment duration : 2-3 months maximum.

 

RULES FOR THE CORRECT ADMINISTRATION

Take with meals (at noon and dinner).

 

CONTRAINDICATIONS

- Hypersensitivity to diosmin or other flavonoids.

 

ADVICE TO THE PATIENT

- It is recommended to take the tablets after lunch and dinner.

- This medicine is intended for short-term treatment of venous insufficiency, for periods of less than 2-3 months.

 

PREGNANCY

There is no record of any harmful effects on the human species. Experimental studies have not revealed any teratogenic effects.

Caution should be exercised in prescribing to pregnant women.

 

LACTATION

It is not known whether this drug is excreted in human milk, however, a minimal human milk excretion (1%) has been observed in an animal model study. In the absence of conclusive data on the passage to breast milk, its use during lactation is not recommended.

 

CHILDREN

Not enough clinical experience is available in this age group. Not recommended use.

 

ELDERLY

In one study, there were no significant differences regarding adverse effects between geriatric patients and younger patients. Accepted use.

 

ADVERSE REACTIONS

Diosmin side effects are generally infrequent, mild and transient.

Adverse reactions are described according to each frequency interval, being considered very frequent (> 10%), frequent (1-10%), infrequent (0.1-1%), rare (0.01-0.1%) , very rare (<0.01%) or of unknown frequency (cannot be estimated from the available data).

-Digestive: frequent: [NAUSEAS], [VOMITS], [DYSPEPSIA], [DIARRHEA].

-Neurological / psychological: rare: [HEADACHE], malaise, [VERTIGO].

-Allergic / dermatological: rare: [EXANTEMATIC ERUPTIONS], [PRURITO], [URTICARIA].

 

OVERDOSE

No cases of overdose have been described. The wide therapeutic margin of this specialty determines that the risk of poisoning is practically nil.

Package Leaflet Daflon 500 Mg 30 Coated Tablets

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